January 2008

CURRICULUM VITAE

MICHAEL K. SKINNER

Personal Data:

Name: Michael Kirtland Skinner

Marital Status: Married, 2 Children

Place of Birth: Redmond, Oregon (www.skinnerfamilynw.org)

Citizenship: USA

Current Address: Center for Reproductive Biology

School of Molecular Biosciences

Washington State University

Pullman, WA 99164-4231

Telephone: (509) 335-1524 FAX: (509) 335-2176

Email: skinner@wsu.edu

Web Site: www.skinner.wsu.edu

www.reproduction.wsu.edu

www.biotechnology.wsu.edu

Education:

Ph.D. in Biochemistry, 1982, Washington State University, Pullman, Washington

B.A. in Chemistry, 1979, Reed College, Portland, Oregon

A.S. in General Science, 1977, Warner Pacific College, Portland, Oregon

Research Interests:

Molecular, Cellular and Physiological Approach to the Study of Reproductive Biology.

1) Cell-cell interactions (e.g. mesenchymal-epithelial cell interactions)

2) Control of gametogenesis (i.e. somatic cell function and endocrine control)

3) Regulation of gonadal cell function and differentiation (e.g. transcriptional control)

4) Reproductive toxicology of endocrine disruptors (i.e. transgenerational epigenetics)

5) Epigenetic transgenerational actions of environmental factors on reproduction and disease.

Current Specific Research:

1) Actions of endocrine disruptors on embryonic testis development that cause epigenetic transgenerational effects on male fertility and other diseases.

2) Peritubular (Myoid) cell-Sertoli cell interactions in the testis via locally produced regulatory proteins and the hormonal and developmental control of these interactions.

3) The control of gonadal (e.g. testis) development and somatic cell differentiation through an examination of transcriptional regulation (e.g. basic helix-loop-helix factors) of cellular differentiation.

4) Theca cell-granulosa cell interactions in the ovary via locally produced regulatory proteins and the hormonal and developmental control of these interactions.

5) Ovarian cell-cell interactions in the control of primordial follicle assembly and development.

Professional Experience:

2002-present Director, Center for Integrated Biotechnology, Washington State University, Pullman, WA

The WSU Center for Integrated Biotechnology (www.biotechnology.wsu.edu) has approximately 170 faculty and involves over 22 departments and 7 colleges. The Core laboratories and research program project areas provide an inter-disciplinary integration of research in the biotechnology area. The education programs and industry interaction activities are also components of the Center.

1996-present Director, Center for Reproductive Biology, joint Center with Washington State University, Pullman, WA and the University of Idaho, Moscow, ID.

The WSU and UI Center for Reproductive Biology (www.reproduction.wsu.edu) currently has approximately 100 faculty from 18 different departments and seven different Colleges. The Center is the largest University based Reproductive Biology Research Center in the world. It currently has program areas including Testis Biology, Fish Reproduction, Reproductive Toxicology, and Plant Reproduction. The Center also has 13 Core Laboratories that provide centralized services from a Genomics Core Lab to a Transgenic Core Lab. The Center has associated approximately 120 graduate students and 250 staff and fellows.

1999-present Professor, School of Molecular Biosciences, Washington State University, Pullman, WA.

1996-1999 Professor, Department of Genetics and Cell Biology, Washington State University, Pullman, WA.

1991 - 1996 Member, Reproductive Endocrinology Center and the Developmental Biology Program in Biological Sciences, University of California, San Francisco, CA.

1991 - 1996 Associate Professor, Department of Physiology, University of California, San Francisco, CA.

1991 - 1996 Associate Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA. Research was designed to investigate the mechanisms regulating cellular function, cell-cell interaction and cellular differentiation, with emphasis in the area of reproductive biology.

1984-1991 Assistant Professor, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN. Research dealt with an analysis of cellular functions and cell-cell interactions in the testis and ovary.

1982-1984 MRC Postdoctoral Fellow, C.H. Best Institute, University of Toronto, Toronto, Ontario, Canada, in the laboratory of Dr. Irving B. Fritz. Research dealt with cell-cell interactions in the testis via basement membrane matrix components and soluble peptides.

1979-1982 Research Assistant, Biochemistry/Biophysics Program, Washington State University, Pullman, WA, in the laboratory of Dr. Michael D. Griswold. My research dealt with an investigation of Sertoli cell functions through a study of secreted proteins.

1978-1979 General Chemistry Teaching Assistant and Research Assistant, Reed College, Portland, OR, in the laboratory of Dr. W. Block. Research dealt with an investigation of the enzyme kinetics of alcohol dehydrogenase as effected by irreversible inhibitors.

1977-1978 Medical Laboratory Technician, Western States College Clinical Laboratory, Portland, OR. I was the assistant to the director (W.C. Davis) in establishment of new assays and quality control.

Teaching Interests and Experience:

Areas which utilize a biochemical and molecular approach to study cell biology and physiology. Specific interests are cell-cell interactions, molecular and cellular endocrinology, developmental cytodifferentiation, and signal transduction.

2000-present Biochemical Signaling in Animals, Plants and Microorganisms, MBioS 561,

(even years) Course Director, 13 – 2 hour lectures, 25-30 students, Spring Semester, WSU Pullman, WA

1997-present Molecular and Cellular Reproduction, MBioS 528, AS 558, UI Biol 559

(odd years) thirty-six 2 hour lectures and discussion sessions, 25-30 students, Spring Washington State University, Pullman, WA.

2004- present Bioethics, Philosophy 530, Co-course Director with Daniel Holbrook and Bryan Slinker, 13-2hr discussion sessions, 30 students, Fall semester, WSU , Pullman, WA

2001- 2006 Advanced Cell Biology, MBioS 401/501, thirteen 1 hour lectures, 100 students, Spring Semester, Washington State University, Pullman, WA.

1999, 2000 Genetics and Cell Biology, Gen CB 550, Cell Biology, eight 1.5 hour lectures, 10 students, Fall semester, Washington State University, Pullman, WA.

1999 Principles of Animal Development, Zool 320, two 1.5 hour lectures, 10 students, Fall Semester, Washington State University, Pullman, WA.

1998-2001, Protein Biotechnology, BC/BP 574, one 2 hour lecture, 20 students, Fall semester,

2005, 2007 Washington State University, Pullman, WA.

1998-2000 Advanced Reproduction, AS 550, four 2 hour lectures, 10 students, Spring semester, Washington State University, Pullman, WA.

1998 Biochemical Signaling in Plants, Animals, and Microoganisms Biochem/Biophysics 561, two 2 hour lectures, 26 students, Spring semester, Washington State University, Pullman, WA.

1997 GenCB 592, BC/BP 592, Zool 592, Advanced Topics in Cell Biology, ≥Reproductive Biology,≤ course Director, twenty-six 2 hour sessions, 20 students, Spring semester, Washington State University, Pullman, WA.

1993, 1995 Ob/Gyn & Reprod. Sci., 210, Molecular and Cellular Biology of Reproduction, Course Director, ten 2 hour lectures and ten 2 hour discussions, Winter Quarter, University of California, San Francisco, CA.

1994-1996 Biomedical Sciences BMS 225B, "Integrative Cellular and Molecular Biology of Human Organ Systems," selected lectures on gametogenesis and testis biology, Winter Quarter, University of California, San Francisco, CA.

1992-1996 Physiology 101, Endocrinology, Mini Course: Reproductive Endocrinology, six 2 hour lectures/discussions, Spring Quarter, University of California, San Francisco, CA.

1992-1996 Physiology 120, Mammalian Physiology, four selected 1 hour lectures on "Reproductive Endocrinology," Winter Quarter, University of California, San Francisco, CA.

1991 Chemistry 106, Undergraduate course on Advanced Topics in Chemistry, selected lecture on "Applications of Chemistry to Biological Systems: The concept of Pharmacology," Vanderbilt University, Nashville, TN.

1988, 1989 Pharmacology 328, Molecular and Cellular Pharmacology of Reproduction, Course Director, seven 2 hour lectures, Fall semester, Vanderbilt University, Nashville, TN.

1987, 1989 Biochemistry/Cell Biology 341, Reproductive Biology, selected 2 hour lectures on "Cell-Cell Interactions in the Regulation of Gonad Function," Vanderbilt University, Nashville, TN.

1985-1990 Pharmacology 324-2, Pharmacological Techniques and Instrumentation, selected 2 hour lectures on "Cell Culture: Methods and Selected Applications" and "Radioisotope Techniques: Detection Methods" and "Protein Chromatography and Electrophoresis," Vanderbilt University, Nashville, TN.

1982 BC/BP 366, General Biochemistry Laboratory, Lecturer and Assistant in laboratory. Washington State University, Pullman, WA.

1978-1979 Chem. 106, General Chemistry, Teaching Assistant. Reed College, Portland, OR. Supervisor: Dr. W. Block.

1978-1979 Bio-Organic Chemistry, Course Director, Western States College, Portland, OR.

Awards and Recognitionπs:

2008 Discover Magazine, Research selected as one of the top 100 discoveries of 2007, Discover, The Year in Science, January 2008, #22, page 40

2007 PBS NOVA Science Documentary, Research Selected as Epigenetic Topic of Documentary, ≥Ghosts in Your Genes≤, aired October 2007

2006 Sahlin Faculty Excellence Award for Research, Scholarship and the Arts, Washington State University

2006 Discover Magazine, Research Selected as one of the top 100 discoveries of 2005, Discover, Year in Science, January 2006, Vol 27, page 49.

2005 Ralph Yount Research Excellence Award, School of Molecular Biosciences, Washington State University

2005 BBC Horizon Science Documentary, Research Selected as Epigenetic Topic of Documentary, ≥The Ghosts in Your Genes≤, aired October 2005.

2003- 2006 Elected, Board of Directors, Centers and Parks representative, Biotechnology Industry Organization (BIO), (largest biotechnology industry organization in the world)

2004-2007 Elected by Society membership, Executive Council (i.e. Board), American Society of Andrology (ASA)

2000-present Appointed, Journal of Andrology, Editorial Board.

2006-present Appointed, Epigenetics, Editorial Board.

1999-2003 Appointed, Biology of Reproduction, Editorial Board.

1996-2000 Appointed, Endocrinology, Editorial Board.

1986-1990 PEW Scholar Award, PEW Scholar Program in Biomedical Sciences, PEW Memorial Trust.

1986 Faculty Development Award in Pharmacology, Pharmaceutical Manufacturers Association.

1983-1984 Postdoctoral Fellowship Award, Medical Research Council (Canada).

1981-1982 Holland Graduate Fellowship Award, Washington State University, Pullman, WA.

1978-1979 Steinbeck Undergraduate Scholarship Award, Steinbeck Trust, Reed College, Portland, OR.

Grants and Fellowships: Total Peer Reviewed Funding Secured from 1985 ($18,660,902).

Current:

2006-2011 NIH R01 HD043093-01≥Ovarian Primordial Follicle Development.≤ Principal Investigator: Michael K. Skinner, $1,450,000.

2004-2009 NIH R01 ES012974-01 ≥Epigenetic Transgenerational Endocrine Disruptor Actions.≤ Principal Investigator: Michael K. Skinner, $1,284,500.

2003-2008 NIH R01 HD 043841-01, ≥Cell-Cell Interactions in Testis Development≤,

Principal Investigator: Michael Skinner, $ 1,321,200

Pending:

2007-2009 NIH R01, "Epigenetic Influences on Behavior." Principal Investigator: David C Crews, UT Austin, Co-PI: Michael K. Skinner $80,000 for WSU.

2008-2013 NIH R01 HD34707-06, "Sertoli Cell Differentiation and Testis Development." Principal Investigator: Michael K. Skinner, $1,475,000.

Past:

1999-2003 EPA STAR R827405-01, " Endocrine Disruptors and Testis Development." Principal Investigator: Michael Skinner, $534,583.

1998-2002 NIH R01 HD34707-05, "Sertoli Cell Differentiation and Testis Development." Principal Investigator: Michael K. Skinner, $965,000.

1996-2000 NIH R01 HD33372-01, "Mesenchymal-Epithelial Cell Interactions in the Ovary." Principal Investigator: Michael K. Skinner, $1,154,638.

1997-2001 NIH P01 CA 64602-01, "Biology of Ovarian Cancer Program Project." Principal Investigator: Michael Skinner, $5,493,825; Project #1 $1,099,642.

1993-1997 NIH DK 45889-01, "Cell-Cell Interactions in the Prostate." Principal Investigator: Michael K. Skinner, $1,026,938.

1993-1997 NIH R01 CA 59831-02, "Growth Factors in Prostatic Carcinogenesis." Co-Principal Investigator: Michael Skinner with Gerald Cunha, $1,250,566.

1994-1996 USDA, "Mesenchymal Growth Factors in the Bovine Ovary." Principal Investigator: Michael K. Skinner, $187,000.

1989-1995 NIH 2 R01 HD20583-09, "Cellular Functions and Interactions in the Testis." Principal Investigator: Michael K. Skinner, $1,667,247.

1992-1994 USDA, "Transforming Growth Factor-fl Gene Expression and Action in the Bovine Ovary." Principal Investigator: Michael Skinner, $240,000.

1992 Academic Senate Grant, University of California, San Francisco, Institutional Grant, $12,412.

1992 REAC-Clough Fund Grant, University of California, San Francisco, Institutional Grant, $13,600.

1987-1991 NIH 1 R01 HD20922-01-03, "Cellular Functions and Interactions in the Ovary." Principal Investigator: Michael K. Skinner, $419,847.

1986-1991 PEW Scholar Award Program, $200,000.

1988-1990 USDA, 8701258, "Transforming Growth Factor-fl Gene Expression and Action in the Bovine Ovary." Principal Investigator: Michael K. Skinner, $200,000.

1986-1989 NIH R01 HD20583-03, "Cellular Functions and Interactions in the Testes." Principal Investigator: Michael K. Skinner, $492,770.

1986-1988 Pharmaceutical Manufacturers Association, 1986 Faculty Development Award in Pharmacology, $50,000. (Not able to accept due to acceptance of PEW Scholar Award).

1984-1987 Mellon Foundation Grant, Vanderbilt University Reproductive Biology Research Center Institutional Grant, $249,000.

1986-1987 American Cancer Society, Vanderbilt Institutional Research Grant IN-25Y, $7,000.

1985-1986 Biomedical Research Support Grant, Vanderbilt University Institutional PHS Grant RR-05424, $8,000.

Patents:

2005 Application: Filed 10/05; WSU; ≥WSURF Ref 610; M&A Ref 30847.USP1 USSN 60/726,969 ≥Cancer Chemotherapy Compositions Comprising PI3K Pathway Modulators and Triptolide.≤

2005 Application: Filed 4/05; WSU; ≥USN 60/566,685 ≥Modified Cells Expressing a Protein that modulates activity of bHLH proteins, and uses thereof.≤

2005 Application: Filed 5/05; M&A Ref. 30857.1USP1, USSN 60/683,134; ≥Methods For Diagnosing Epigenetic, Transgenerational Effects Of Environmental Toxins On Mammalian Germ-Lines And Treating Associated Diseases.≤

2004 Application: Filed 8/04; Monash University, Australia & WSU; USSN 60/604,971; ≥FSH Regulated Genes and Entitled ≥A Method of Diagnosis≤.≤

2003 Application: File 8/03; USSN# 10/647,426; Title: ≥A method of determining tumor characteristics by determining abnormal copy number of lipid-associated genes.≤

2000 Application: Filed 10/00; USSN# 09/661,998; Title: ≥Enzyme method for detecting sphinogine-1-phosphate (SIP) and use as marker in disease.≤

1997 Application: Filed 11/18/96; USSN# 08/751,782; Title: ≥cDNA collections encoding proteins regulated.≤ Field of Invention: Prostate cDNA library and identification of genes associated with apoptosis for diagnostic disease (i.e. cancer and benign prostatic hyperplasia).

1988 Application Submitted: VU 8873 filed 12/27/88; USSN, #291,682; Title: "Testes Function Enhancing Proteins." Field of Invention: Testicular paracrine factors which are involved in male fertility and male contraception.

Industrial and Academic Interactions:

2007-present Scientific Consultant, PregLem Biotechnologies, Geneva Switzerland.

2007-present Scientific Consultant, Rosetta Inpharmatics/Merck Pharmaceutical, Seattle, WA.

2006-2007 Scientific Consultant, Institute for Systems Medicine, Spokane, WA.

2003- 2006 Board of Directors, Biotechnology Industry Organization (BIO), Centers and Parks representative.

BIO is the worldπs largest industry organization representing over 1,000 companies and institutions.

1999-2003 Director, Founder and Chief Scientific Officer, Atairgin Technologies, Irvine CA.

Atairgin Technologies Inc. is a biotechnology company focused on early diagnostics and therapeutics. Early stage ovarian cancer and breast cancer blood tests are lead products. The company had approximately 50 employees and was located in Irvine, California. The company was originally established and operated for two years out of the WSU Research and Technology Park. The company was majority acquired by two venture groups and moved to Cleveland, Ohio and renamed LPL Technologies, Inc. in 2003.

1996-1999President, Director, and Founder, Atairgin Technologies Inc., Pullman, WA;

Lead Products in Reproductive Cancer Diagnostics and Therapeutics. Company initially established in the WSU Technology Park.

2002-2003 Chairman, Board of Directors, Bio~Origyn, Spokane, WA

Bio~Origyn had a base technology in bioactive carbohydrates with lead products in fertility treatments and blood processing. The company was a start-up biotechnology company that spun out of WSU.