BIOGRAPHICAL SKETCH
Skinner, Michael K.
Professor and Director
Education/Training
Warner Pacific College, Portland,
OR
A.S.
1977 General
Science
Reed College, Portland,
OR
B.A.
1979 Chemistry
Washington State University, Pullman, WA
Ph.D.
1982
Biochemistry
University of Toronto, Toronto, Ont., Canada
Post-doc 1982-84 Biochem/Physiol.
Research/Professional Experience:
1996-2008 Director, Center for Reproductive Biology,
Washington State University, Pullman, Washington.
1996-2008 Professor, School of Molecular Biosciences,
Washington State University, Pullman, Washington.
1991-1996 Member, the Reproductive Endocrinology Center
and the Developmental Biology Program in Biological
Sciences, University of California, San Francisco.
1991-1996 Associate Professor, Department of Obstetrics,
Gynecology and Reproductive Sciences and Department of
Physiology, University of California, San Francisco,
CA.
1985-1991 Assistant Professor, Department of
Pharmacology, Vanderbilt University, School of Medicine,
Nashville, Tennessee. Research dealt with an analysis of
cellular functions and cell-cell interactions in the
testis and ovary.
1982-1984 MRC Postdoctoral Fellow, C.H. Best Institute,
University of Toronto, Toronto, Ontario, Canada, in the
laboratory of Dr. Irving B. Fritz. Research dealt with
cell-cell interactions in the testis via basement
membrane components and soluble peptides.
1979-1982 Research Assistant, Biochemistry/Biophysics
Program, Washington State University, Pullman,
Washington, in the laboratory of Dr. Michael D. Griswold.
Research dealt with an investigation of Sertoli cell
functions through a study of secreted proteins.
1978-1979 General Chemical Teaching Assistant and
Research Assistant, Reed College, Portland, Oregon, in
the laboratory of Dr. W. Block. Research consisted of
studies on the enzyme kinetics of alcohol dehydrogenase
as effected by irreversible inhibitors.
Publications: (selected from over
190)
Nilsson EE, Doraiswamy V, and MK Skinner (2003)
Transforming Growth Factor-Beta (TGFβ1, TGFβ2
and TGFβ3) expression during
bovine ovarian antral follicle development. Molecular
Reproduction and Development 66:237-246.
Kezele P and MK Skinner (2003) Regulation of ovarian
primordial follicle assembly and development by estrogen
and progesterone: endocrine model of follicle assembly.
Endocrinology 144:3329-3337.
Cupp, A.S., Uzumcu, M, Phillips, B, Dirks, K, and MK
Skinner (2003) Effect of Transient Embryonic In Vivo
Exposure of the Endocrine Disruptor Methoxychlor on
Embryonic and Postnatal Testis Development and Function.
Journal of Andrology 24(5): 736-745.
Cupp AS, Uzumcu, M, and MK Skinner (2003) Chemotactic
Role of Neurotropin 3 in the embryonic testis that
facilitates morphological male sex determination. Biology
of Reproduction 68:2033-2037.
Nilsson EE and MK Skinner (2003) Bone Morphogenetic
Protein –4 acts as an ovarian follicle survival
factor and promote primordial follicle development.
Biology of Reproduction 69:1265-1272.
Chaudhary, J., Sadler-Riggleman, I and Skinner, M.K.
(2004) Identification of a novel Sertoli cell gene
product SERT that influences follicle stimulating hormone
actions. Gene 324:79-88.
Nilsson EE and MK Skinner (2004) Kit ligand and basic
fibroblast growth factor interactions in the induction of
ovarian primordial to primary follicle transition.
Molecular and Cellular Endocrinology 214:19-25.
Saxlund MA, Sadler-Riggleman I, and MK Skinner (2004)
Role of Basic Helix-Loop-Helix (bHLH) and CREB
Transcription Factors in the Regulation of Sertoli Cell
Androgen Binding Protein Expression. Molecular
Reproduction and Development 68:269-278.
Uzumcu M, Suzuki H, and MK Skinner (2004) Effect of the
Anti-Androgenic Endocrine Disruptor Vinclozolin on
Embryonic Testis Cord Formation and Postnatal Testis
Development and Function. Reproductive Toxicology
18:765-774.
Chaudhary J, Sadler-Riggleman I and MK Skinner (2005) The
Helix-Loop-Helix Inhibitor of Differentiation (Id)
Proteins Induce Post-Mitotic Terminally Differentiated
Sertoli Cells to Re-Enter the Cell Cycle and Proliferate.
Biology of Reproduction 72:1205-1217.
Kezele PR, Ague J, Nilsson EE and MK Skinner (2005)
Alterations in the ovarian transcriptome during
primordial follicle assembly and development. Biology of
Reproduction 72:241-255.
Cupp, A.S. and Skinner, M.K. (2005) Embryonic Sertoli
Cell Differentiation. In: Sertoli Cell Biology eds.
M.D. Griswold and M.K. Skinner, Elsevier -Academic Press,
San Diego, CA, pp. 43-70.
Skinner, M.K. (2005) Sertoli Cell Secreted Regulatory
Factors. In: Sertoli Cell Biology eds. M.D.
Griswold
and M.K. Skinner, Elsevier -Academic Press, San Diego,
CA, pp. 107-120.
Chaudhary, J. and Skinner, M.K. (2005) Transcription
Factors in Sertoli Cells. In: Sertoli Cell Biology
eds.
M.D. Griswold and M.K. Skinner, Elsevier -Academic Press,
San Diego, CA, pp. 251-280.
Skinner, M.K. (2005) Sertoli Cell-Somatic Cell
Interactions. In: Sertoli Cell Biology eds. M.D. Griswold
and M.K. Skinner, Elsevier -Academic Press, San Diego,
CA, pp. 317-328.
Small CL, Shima JE, Uzumcu M,Skinner MK and MD Griswold
(2005) Profiling gene expression during the
differentiation and development of the murine embryonic
gonad. Biology of Reproduction 72:492-501.
Ye X, Hama K, Contos J, Anliker B, Inoue A, Skinner MK,
Suzuki H Amano T, Kennedy G, Arai H, Aoki J and Chun J.
(2005) LPA3-mediated lysophosphatidic acid signaling in
implantation and embryo spacing. Nature
435:104-108.
Anway M, Cupp AS, Uzumcu M and MK Skinner (2005)
Epigenetic transgenerational actions of endocrine
disruptors and male fertility. Science
308:1466-1469.
Meachem SJ, Ruwanpura SM, Ziolkowski J, Ague J, Skinner
MK and KL Loveland. (2005) Developmentally distinct in
vivo effects of FSH on proliferation and apoptosis during
testis maturation. Journal of Endocrinology
186:429-446.
Muir T, Sadler-Riggleman I, Stevens JD, and MK Skinner
(2005) Role of the basic helix-loop-helix protein ITF2 in
the hormonal regulation of Sertoli Cell Differentiation.
Molecular Reproduction and Development 73:491-500.
Muir T, Sadler-Riggleman I, Stevens JD, and MK Skinner
(2005) Role of the basic helix-loop-helix transcription
factor, scleraxis, in the regulation of Sertoli cell
function and differentiation. Molecular
Endocrinology.19:2164-2174.
Westfall S, and MK Skinner (2005) Inhibition Of
Phosphatidylinositol 3-Kinase (PI3K) Sensitizes Ovarian
Cancer Cells To Carboplatin And Allows Adjunct
Chemotherapy Treatment. Molecular Cancer Therapeutics
4:1764-1771.
Kezele P, Nilsson EE and MK Skinner (2005) Keratinocyte
growth factor acts as a mesenchymal factor to promote
ovarian primordial to primary follicle transition.
Biology of Reproduction 73:967-973.
Skinner MK. (2005) Regulation of primordial follicle
assembly and development. Hum Reprod Update.
11:461.
Anway MD, Memon M, Uzumcu M, and MK Skinner (2006)
Transgenerational effect of the endocrine disruptor
vinclozolin on male spermatogenesis. Journal of Andrology
27:868-879.
Skinner MK and Anway MD (2006) Seminiferous cord
formation and germ cell programming: epigenetic
transgenerational actions of endocrine disruptors. Annals
New York Academy of Science 1061:18-32.
Anway MD, Leathers C and MK Skinner (2006) Endocrine
Disruptor Vinclozolin Induced Epigenetic
Transgenerataional Adult Onset Disease. Endocrinology
147:5515-5523.
Chang HS, Anway MD, Rekow SS, and Skinner MK (2006)
Transgenerational Epigenetic Imprinting of the Male
Germ-Line by Endocrine Disruptor Exposure During Gonadal
Sex Determination. Endocrinology 147:5524-5541.
Nilsson EE, Stanfield J, and MK Skinner (2006)
Interactions between progesterone and tumor necrosis
factoralpha in the regulation of primordial follicle
assembly. Reproduction 132:877-886.
Nilsson EE, Detzel C, and MK Skinner (2006)
Platelet-derived growth factor modulates the primordial
to primary follicle transition in rat ovaries.
Reproduction 131:1007-1015.
Skinner MK (2006) Epigenetic transgenerational actions of
endocrine disruptors through the male germ-line. In:
Male-Mediated Development Toxicology. Ed. D. Anderson and
MH Brinkworth, Royal Society of Chemistry, Cambridge, UK,
CH001, pp. 1-4.
Anway, MD and MK Skinner (2006) Epigenetic
Transgenerational Actions of Endocrine Disruptors.
Endocrinology 147:S43-S49.
Nilsson EE, Rogers N and MK Skinner (2007) Actions of the
anti-müllerian hormone (AMH) on the ovarian
transcriptome to inhibit primordial to primary follicle
transition. Reproduction 134:209-221.
Jirtle RL and MK Skinner (2007) Environmental Epigenomics
and Disease Susceptibility. Nature Genetics Rev.
8:253-262.
Crews D, Gore AC, Hsu TS, Dangleben NL, Spinetta M,
Schallert T, Anway MD and Skinner MK (2007)
Treansgenerational epigenetic imprints on mate
preference. Proc Natl Acad Sci 104:5942-5946.
Clement TM, Anway MD, Uzumcu M and MK Skinner. (2007)
Regulation of the gonadal transcriptome during sex
determination and testis morphogenesis: candidate
regulatory genes. Reproduction 134:455-472.
Skinner MK (2007) Epigenetic Transgenerational Toxicology
and Germ Cell Disease. International Journal of Andrology
30:393-397.
Skinner MK (2007) Epigenetic Transgenerational Disease
Etiology. Pediatric Research 61:48R-50R.
Anway MD and MK Skinner (2007) Epigenetic
Transgenerational Actions of Vinclozolin on the
Development of Disease and Cancer. Critical Reviews in
Oncogenesis 13:75-82.
Anway MD and MK Skinner (2008) Epigenetic Programming of
the Germ Line: Effects of Endocrine Disruptors on the
Development of Transgenerational Disease. Reproductive
Biomedicine Online. 16:23-25.
Westfall S, Nilsson EE and MK Skinner (2008) Role of
triptolide as an adjunct chemotherapy for ovarian cancer.
Chemotherapy 54:67-76.
Anway MD, Rekow SS, and MK Skinner (2008)
Transgenerational epigenetic programming of the testis
transcriptome by endocrine disruptor exposure at sex
determination. Genomics 91:30-40.
Skinner MK (2008) What is an epigenetic transgenerational
phenotype? F3. Reproductive Toxicology. 25:2-6.
Anway MD and Skinner MK (2008) Epigenetic
transgenerational effects of the endocrine disruptor
vinclozolin on the prostate transcriptome and adult onset
prostate disease. Prostate. 68:517-529.
Muir T, Wilson-Rawls J, Stevens JD, Rawls A, Schweitzer
R, Kang C, Skinner MK. (2008) Integration of CREB and
bHLH transcriptional signaling pathways through direct
heterodimerization of the proteins: Role in muscle and
testis development. Mol Reprod Dev. 75(11):1637-52.
Skinner MK, Schmidt M, Savenkova MI, Sadler-Riggleman I,
Nilsson EE. (2008) Regulation of granulosa and theca cell
transcriptomes during ovarian antral follicle
development. Mol Reprod Dev. 75(9):1457-72.
Stevens JD, Roalson EH, and Skinner MK. (2008)
Phylogenetic and expression analysis of the basic
helix-loop-helix transcription factor gene family:
genomic approach to cellular differentiation.
Differentiation. 2008 Jun 13. [Epub ahead of print]
Dole G, Nilsson EE, Skinner MK. (2008) Glial-derived
neurotrophic factor promotes ovarian primordial follicle
development and cell-cell interactions during
folliculogenesis. Reproduction. 135(5):671-82.
Nilsson EE, Anway MD, Stanfield J, Skinner MK. (2008)
Transgenerational epigenetic effects of the endocrine
disruptor vinclozolin on pregnancies and female adult
onset disease. Reproduction. 135(5):713-21.
Ye X, Skinner MK, Kennedy G, Chun J. (2008) Age-dependent
loss of sperm production in mice via impaired
lysophosphatidic acid signaling. Biol Reprod.
79(2):328-36.
Memon MA, Anway MD, Covert TR, Uzumcu M, Skinner MK.
(2008) Transforming growth factor beta (TGFbeta1,
TGFbeta2 and TGFbeta3) null-mutant phenotypes in
embryonic gonadal development. Mol Cell Endocrinol. 2008
Aug 26. [Epub ahead of print]
Anway MD, Rekow SS, Skinner MK. (2008) Comparative
anti-androgenic actions of vinclozolin and flutamide on
transgenerational adult onset disease and
spermatogenesis. Reprod Toxicol. 2008 Aug 13. [Epub ahead
of print]
Hahn KL, Beres B, Rowton MJ, Skinner MK, Chang Y, Rawls
A, Wilson-Rawls J. (2008) A deficiency of lunatic fringe
is associated with defects of the rete testis.
Reproduction. 2008 [Epub ahead of print]
Research Projects:
ACTIVE
• NIH R01 HD 43841-01, 4/1/03-3/30/08, 25%,
Cell-Cell Interactions and Testis Development $
1,321,200
This grant deals with the growth factors involved in the
onset and progression of embryonic sex
determination and testis development. No overlap exists
between this grant and the current proposal.
• NIH R01 HD 043093, 4/1/06-3/30/11, 15%, Ovarian
Primordial Follicle Development $1,450,000 This
project deals with the cellular and molecular control of
ovarian primordial follicle development. No
overlap exists between this grant and the current
proposal.
• NIH R01 ES012974-01, 12/1/04-11/31/08, 25%,
Transgenerational Epigenetic Endocrine Disruptor
Actions on Male Fertility. $1,284.500. This project deals
with the examination of endocrine disruptors on
testis development and male fertility. This grant
investigates the mechanisms involved in the
phenomena
and the current proposal is a competitive renewal of this
grant.
• DOD, USAMRMC BAA Log No 07087010, 25%, Epigenetic
Origins of Disease and Impact of
Environmental Toxicants in Iraq Theater of
Operations
This project investigates the actions of four different
mixtures of military relevant compounds to examine
potential transgenerational actions on adult onset
disease. This proposal examines different compounds
and not mechanism, so no overlap exists.
PENDING
• NIH R01 HD 43841-06, 25%, Cell-Cell Interactions
and Testis Development
This project investigates transcription factor and growth
factor mediated cell-cell interactions involved in
the onset and progression of embryonic gonadal sex
determination and testis development.
• NIH R01 ES012974-01, 12/1/08-11/31/13, 25%,
Transgenerational Epigenetic Endocrine Disruptor
Actions on Male Fertility. This project deals with the
examination of endocrine disruptors on testis
development and male fertility. This grant investigates
the mechanisms involved in the phenomena and
the current proposal is a competitive renewal of this
grant.