Position Title: ASSISTANT RESEARCH PROFESSOR
Education/Training
TAMIL NADU AGRICULTURAL UNIVERSITY,
INDIA
B.V.SC.* 1975-80 VET.
& ANIMAL SCIENCEVETERINARY (MADRAS
COLLEGE)
*Equivalent toD.V.M. degree
TAMIL NADU AGRICULTURAL UNIVERSITY,
INDIA
M.V.SC. 1982-84
ANIMAL BREEDING &
(MADRAS VETERINARY COLLEGE)
GENETICS
UNIVERSITY OF BRITISH COLUMBIA, VANCOUVER,
BC, PH.D.
1991-96
ANIMAL SCIENCE
CANADA
(REPRODUCTION)
Research/Professional Experience:
1) 09/08-present Assistant Research Professor, Washington
State University, Pullman, WA, USA
2) 12/01-08/08 Research Fellow, Res. Investigator, Res.
Associate University of Michigan, Ann Arbor, MI,
USA
3) 01/00-11/01 Associate Scientist Kansas State
University Manhattan, KS, USA
4) 06/96-12/99 Postdoctoral Research Associate University
of Missouri-Columbia, USA
5) 09/93-05/96 UBC Graduate Research Fellow University of
British Columbia, Canada
6) 09/92-09/94 Graduate Teaching Assistant (Physiology),
Univ. of British Columbia, Canada
7) 09/91-08/92 Graduate Research Assistant (NSERC),
University of British Columbia, Canada
8) 01/91-08/91 Assistant Professor (Bull Semen Bank) T.N.
Agricultural University, India
9) 02/85-12/90 Assistant Professor (Abortion in Cattle)
T. N. Agricultural University, India
10) 01/82-11/82 Extension Officer (Animal Husbandry)
Tamil Nadu, India
11) 04/81-09/81 Veterinary Assistant Surgeon Tamil Nadu,
India
Publications:
(28) Manikkam M, Thompson RC, Herkimer C, Welch KB, Flak
J, Karsch FJ, Padmanabhan V. 2008
Developmental Programming: Impact of Prenatal
Testosterone Excess on Pre- and Postnatal
Gonadotropin
Regulation in Sheep. Biol Reprod 78:648-660.
(27) Steckler T, Manikkam M, Inskeep EK, Padmanabhan V.
2007 Developmental Programming: Follicular
persistence in prenatal testosterone-treated sheep is not
programmed by androgenic actions of testosterone.
Endocrinology 148:3532-3540
(26) Padmanabhan V, Manikkam M, Recabarren S, Foster D
2006 Prenatal testosterone excess programs
reproductive and metabolic dysfunction in the female Mol
Cell Endocrinol 246:165-174
(25) Manikkam M, Steckler TL, Welch KB, Inskeep EK,
Padmanabhan V. 2006 Fetal Programming: Prenatal
Testosterone Treatment Leads to Follicular Persistence /
Luteal Defects. Partial Restoration of Ovarian
Function by Cyclic Progesterone Treatment. Endocrinology.
147:1997-2007
(24) Sarma HN, Manikkam M, Herkimer C, Dell'Orco J, Welch
KB, Foster DL, Padmanabhan V. 2005 Fetal
programming: excess prenatal testosterone reduces
postnatal luteinizing hormone, but not
follicle-stimulating
hormone responsiveness, to estradiol negative feedback in
the female. Endocrinology 146:4281-91.
(23) Hampton JH, Manikkam M, Lubahn DB, Smith MF,
Garverick HA 2004 Androgen receptor mRNA
expression in the bovine ovary Dom Anim Endocrinol
27:81-88
(22) Manikkam M, Crespi E, Doop D, Herkimer C, Lee JS, Yu
S, Brown MB, Foster DL, Padmanabhan V 2004
Fetal Programming: Prenatal Testosterone Excess Leads to
Fetal Growth Retardation and Postnatal Catch-up
Growth in Sheep Endocrinology 145:790-798.
(21) Manikkam, M., Li, Y., Mitchell, B. M., Mason, D. E.,
Freeman, L. C. (2002). Potassium Channel
Antagonists Influence Porcine Granulosa Cell
Proliferation, Differentiation, and Apoptosis. Biol
Reprod 67: 88-
98
(20) Manikkam, M., Bao, B., Rosenfeld, C.S., Yuan, X.,
Salfen, B.E., Calder, M.D., Youngquist, R.S.,
Keisler,
D.H., Lubahn, D.B., Garverick, H.A. 2001. Expression of
the bovine estrogen receptor-β (BER-β)
messenger
ribonucleic acid (mRNA) during the first ovarian
follicular wave and lack of change in the expression of
BER-β
mRNA of second wave follicles after luteinizing hormone
infusion into cows. Anim. Reprod. Sci. 67:159-169.
(19) Manikkam, M., Calder, M.D., Salfen, B.E.,
Youngquist, R.S., Keisler, D.H., Garverick, H.A.
2001.
Concentrations of steroids and gene expression of
steroidogenic enzymes and gonadotropin receptors in
bovine ovarian follicles of first and second waves and
changes in second wave follicles after pulsatile LH
PHS 398/2590 (Rev. 05/01) Page ____6___ Biographical
Sketch Format Page +
infusion. Anim. Reprod. Sci. 67:189-203.
(18) Calder, M.D., Manikkam, M., Salfen, B.S.,
Youngquist, R.S., Lubahn, D.B., Lamberson W.R.,
Garverick,
H.A. 2001. Dominant Bovine Ovarian Follicular Cysts
Express Increased Levels of Messenger RNAs for
Luteinizing Hormone Receptor and 3β-Hydroxysteroid
Dehydrogenase Δ4Δ5 Isomerase Compared to
Normal
Dominant Follicles. Biol. Reprod. 65:471-476.
(17). Garbayo, J.M., Green, J.A., Manikkam, M., Beckers,
J-F.,Kiesling, D.O., Ealy, A.D., Roberts, R.M.
2000.
Caprine pregnancy assoociated glycoproteins (PAG): Their
cloning, expression and Evolutionary Relationship
to other PAG. Mol. Reprod. Dev. 57:311-322.
(16). Rosenfeld CS, Yuan X, Manikkam M, Calder MD,
Garverick HA, Lubahn DB. 1999. Cloning, Sequencing,
and Localization of Bovine Estrogen Receptor-ß
within the Ovarian Follicle. Biol Reprod. 60:
691-697.
(15). Manikkam, M. and Rajamahendran, R. 1997.
Progesterone-induced Atresia of the Proestrus
Dominant
Follicle in the Bovine Ovary: Changes in Diameter, the
Insulin-like Growth Factor System, Aromatase
Activity,
Steroid Hormones and Apoptotic Index. Biol. Reprod.
57:580-587.
(14). Manikkam, M., Rajamahendran, R. and Rawlings, N.C.
1996. Effect of bovine follicular fluid
administration during or after norgestomet treatment on
the fate of the proestrus dominant follicle in
heifers.
Anim. Reprod. Sci. 44:149-163.
(13). Manikkam, M., Rajamahendran, R. and Rawlings, N.C.
1995. Effects of bovine follicular fluid and
luteinizing hormone releasing hormone antagonist on the
dominant follicle maintained by a Norgestomet ear
implant in heifers. Can. J. Anim. Sci. 75:71-78.
(12). Rajamahendran, R. and Manikkam, M. 1994. Effects of
exogenous steroid hormones on the dominant
follicle maintained by a Norgestomet implant in heifers.
Can. J. Anim. Sci. 74:457-464.
(11). Taylor, C., Manikkam, M. and Rajamahendran, R.
1994. Changes in ovarian follicular dynamics and
luteinizing hormone profiles following different
progestagen treatments in cattle. Can. J. Anim. Sci.
74:273-
279. Previous name used: Mohan M
(10). Manickam, R., Mohan, M., Sadasivam Pillai, K.G.,
Krishnamurti C.R. 1990. Observations on nonsurgical
recovery and transfer of embryos in crossbred cows.
Indian J. Anim. Repr. 11: 121-124.
(9). Manickam, R., Mohan, M., Ramalingam, G. 1989.
Studies on in vitro drug sensitivity of isolates
from
infertile cattle. Indian J. Vet. Med. 8:127-13 1.
(8). Mohan, M., Singh, B.K., Manickam, R. 1989.
Seroepidemiological studies on infectious bovine
rhinotracheitis (IBR) infection in bulls. Indian Vet. J.
66: 914-916.
(7). Balagopal, R., Mohan, M. and Manickam, R. 1989. A
case report on a monster with developmental
anomalies in a Tellicherry goat. Indian Vet. J.
66:179.
(6). Manickam R. Mohan M.1987. Seroepidemiological
studies on infectious bovine rhinotracheitis (IBR)
viral
abortion in cows. Indian J. Anim. Sci. 57
(9):959-961.
(5). Manickam, R. and Mohan, M. 1987. Epidemiological
studies on Brucella abortus infection in milch
cattle.
Indian Vet. J. 64:546-549.
(4). Manickam, R. and Mohan, M. 1987. A note on the
outbreak of Swinepox in Large White Yorkshire
piglets.
Indian J. Vet. Med. 7:71-72.
(3). Mohan, M., Ulaganathan, V., Rodricks, I.M.,
Bhuvanakumar, C.K. and Iyue, M. 1986. Reproduction
rate
and viability of Merino, Nilagiri and halfbred Merino.
II. Age specific replacement rate, and net
reproduction
rate. Trop. Anim. Health Prod. (UK) 18:177-183.
(2). Mohan, M., Ulaganathan, V., Rodricks, I.M.,
Bhuvanakumar, C.K. and lyue, M. 1986. Reproduction
rate
and viability of Merino, Nilagiri and halfbred Merino. I.
Fertility, prolificacy and viability. Trop. Anim.
Health
Prod. (UK) 18:171-176.
(1). Mohan, M. and Ulaganathan, V. 1986. Repeatability of
reproduction rate in Merino, Nilagiri and their
crosses. Indian Vet. J. 63:222-226.